CCL2 anticorps

N° du produit ABIN966545

L’anticorps Monoclonal anti-CCL2 a été validé pour WB et ELISA. Il convient pour détecter CCL2 dans des échantillons de Humain. Il y a 3+ publications disponibles.

Aperçu rapide pour CCL2 anticorps (ABIN966545)

Antigène: CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))

Reactivité: Humain

Hôte: Veuillez nous consulter SVP

Clonalité: Monoclonal

Conjugué: Cet anticorp CCL2 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-CCL2 anticorps

Specificité: Ni-NTA purified recombinant human MCP-1 expressed in E.Coli strain BL21 (DE3).

Purification: Antibodies are purified by protein A affinity chromatography

Isotype: IgG1 kappa

Information d'application

Indications d'application: Dilution: Western Blot: 1:500-1,000
ELISA: 1,000-2,000.

Restrictions: For Research Use only

Stockage

Stock: -20 °C

Références pour anticorps anti-CCL2 (ABIN966545)

Yoshimura, Leonard: "Human monocyte chemoattractant protein-1 (MCP-1)." dans: Advances in experimental medicine and biology, Vol. 305, pp. 47-56, (1992) (PubMed).

Rollins, Morton, Ledbetter, Eddy, Shows: "Assignment of the human small inducible cytokine A2 gene, SCYA2 (encoding JE or MCP-1), to 17q11.2-12: evolutionary relatedness of cytokines clustered at the same locus." dans: Genomics, Vol. 10, Issue 2, pp. 489-92, (1991) (PubMed).

Yoshimura, Yuhki, Moore, Appella, Lerman, Leonard: "Human monocyte chemoattractant protein-1 (MCP-1). Full-length cDNA cloning, expression in mitogen-stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE." dans: FEBS letters, Vol. 244, Issue 2, pp. 487-93, (1989) (PubMed).

Détails sur CCL2

Antigène: CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))

Autre désignation: MCP-1

Sujet: Monocyte chemoattractant protein-1 (MCP-1) is a member of the chemokine-beta family of cytokines. The protein is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. It may play a inprotant role in the initiation and/or progression of pulmonary hypertension (PH). Blockade of a systemic MCP-1 signal pathway in vivo may prevent PH.

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, ER-Nucleus Signaling, Unfolded Protein Response, Phosphorylation & l'infection par le SRAS-CoV-2